Also wondering if our condition meets the provincial gov't "high risk conditions", Did your docs have an opinion on which vaccine given our condition? I was just getting ready to get my shot until I read that. Anesthesia, Critical Care & Pain Medicine, Billing, Insurance & Financial Assistance. At least 2 months after 3rd dose, children aged 6 months4 years can only get a Moderna updated booster, and children aged 5 years can get a Pfizer-BioNTech or Moderna updated booster. I am hetero Factor V Leiden - 2 weeks after getting the 1st pfizer covid vaccine I developed blood clots in my lungs. Importantly, the investigators note that factor V elevation in COVID-19 could cause misdiagnosis of some patients, because under normal circumstances factor V levels are low in the presence of liver dysfunction or DIC. Polyethylene glycol (PEG) is a stabilizer that is used in many medications including plasma derived and recombinant factor products. WebI have the factor V Leiden mutation (heterozygous) and had a DVT at age 25, while on the combined oral contraceptive pill. Pfizer-BioNTech I am a healthy 57 year old breast cancer survivor (6 years) with factor V Leiden. At least 2 months after 3rd dose. Now, as Massachusetts makes vaccines available for residents with two or more COVID risk conditions, many residents are trying to figure out if they qualify. For patients in a clinical study, vaccination should be reported to the study investigators. Yet the mechanisms underlying coagulation disorders in patients with COVID-19 are still unknown. I am hetero Factor V Leiden - 2 weeks after getting the 1st pfizer covid vaccine I developed blood clots in my lungs. Did you qualify because you live in a hotspot or meet the age threshold? I like to have a small glass of white wine (about 3 ounces) each evening before dinner or an occasional (once every three or four weeks) highball with an ounce of vodka or tequila. WebFactor V Leiden is a genetic disorder that causes you to have an increased risk of developing abnormal venous blood clots. The most commonly reported side effects, which typically lasted several days, were pain at the injection site, tiredness, headache, muscle pain, chills, joint pain, and fever. Should I take the vaccination if I am pregnant or breastfeeding? I am concerned about getting the Covid Vaccine, either Moderna or Pfizer. Safe Care CommitmentGet the latest news on COVID-19, the vaccine and care at Mass General.Learn more. Pfizer-BioNTech or Moderna (https://osf.io/a9jdq/?show=view). Its plausible that there may be genetic factors that increase the risk of the AstraZeneca vaccine in some people in a similar way, but at this stage, we dont know. I would encourage anyone to spend some time on these sites, in addition to taking advantage of the use of Google Scholar to be able to see actual studies that have been published, if reading the publications that are meant for patients like us are not enough. A bleeding disorder neither increases the risk for getting coronavirus infection nor having a serious infection, being hospitalized, or dying if you are infected. Recommendations on Administration of Vaccines to Individuals with Bleeding Disorders. UPDATED BOOSTER or risk of disease in a loved one or close contact. Are you taking any medications with one of the following ingredientsone of those ingredients being a PEG? Additional resources Thrombosis - Clot Connect: http://www.clotconnect.org/ Thrombosis - Stop The Clot: Have questions about navigating your Inspire support community or need assistance from one of our Inspire Moderators? More information on prescribing Comirnaty can be found at https://www.fda.gov/vaccines-blood-biologics/comirnaty. The lab tests that usually diagnose DIC were not helpful in these cases.. Factor V Leiden is the name of a specific mutation (genetic alteration) that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels. The vaccine does not contain a preservative. The dosing regimen is two doses of 0.3 mL each, 3 weeks apart. The EUA allows the Janssen COVID-19 Vaccine to be distributed in the U.S. for use in individuals 18 years of age and older.to prevent COVID-19. Four days later, this patient developed a saddle pulmonary embolism, a potentially fatal blood clot occurring at the junction of the left and right pulmonary arteries. My son may suffer from lasting consequences from it as his case is much worse than mine. However, that information will still be included in details such as numbers of replies. Do you have a bleeding disorder or have any issues with bleeding? At this time Im very skeptical about receiving a COVID-19 vaccine because of my reaction to the hep a vaccine. Thrombocytopenia can be inherited, acquired through lifestyle factors over time (such as poor diet combined with alcohol) or brought on by medicines or infections. There are several other vaccines that are in development but have not received EUA. Getting vaccinated is a personal choice. In March 2020, in the early days of the COVID-19 pandemic in Massachusetts, Van Cott and colleagues found that a blood sample from a patient with severe COVID-19 on a ventilator contained factor V levels high above the normal reference range. People who are moderately or severely immunocompromised who have low or no protection after two doses of mRNA vaccines may have an improved immune response after a third primary dose of the same vaccine. I was told that if I didnt respond to the high flow oxygen while waiting to go for an interventional radiology procedure to deliver antithrombolitics to my lungs, I would have to be intubated. One vaccine, the messenger RNA (mRNA) vaccine developed by Pfizer-BioNTech has been approved by the United States from the Food and Drug Administration on August 23, 2021, and will be marketed under the trade name of Comirnaty (koe-mir-na-tee). These typically appear between four and 20 days after vaccination. I still think about how close I felt to death. 1) people who have had a previous blood clot 2) people with a family member who has developed a blood clot 3) people with a hereditary clotting tendency (e.g., factor Recommendations for Fully Vaccinated People, Children and teens aged 6 months17 years, Use of COVID-19 Vaccines Currently Authorized or Approved in the United States, National Center for Immunization and Respiratory Diseases (NCIRD), Possibility of COVID-19 Illness after Vaccination, Investigating Long-Term Effects of Myocarditis, How and Why CDC Measures Vaccine Effectiveness, Monitoring COVID-19 Cases, Hospitalizations, and Deaths by Vaccination Status, Monitoring COVID-19 Vaccine Effectiveness, U.S. Department of Health & Human Services. Dr. Roach regrets that he is unable to answer individual letters, but will incorporate them in the column whenever possible. For people who are immunocompromised, the third primary dose is the final dose of the primary series of an mRNA COVID-19 vaccine. Up to Date: Immediately after they have received an updated booster. The people you live or spend time with can help protect you and themselves by staying up to date on their COVID-19 vaccines too. The Moderna COVID-19 Vaccine is administered as a primary series of two doses, one month apart, to individuals 6 months through 17 years of age. Fact check: COVID-19 vaccines won't cause a zombie apocalypse. Any of the currently authorized COVID-19 vaccines can be offered to people who are pregnant or breastfeeding. Would I be in a priority group to receive the vaccine with a bleeding disorder? The conditions on this list are in alphabetical order. Therefore, if you have the Factor V Leiden mutation, you have an inherited Pfizer-BioNTech As with vaccines for other diseases, you are protected best when you stay up to date with your COVID-19 vaccines for your age group: COVID-19 vaccine and booster recommendations may be updated as CDC continues to monitor the latest COVID-19 data. But for some whove taken the vaccine, platelets appear to stick together in the venous sinuses of the brain, which causes a blockage that prevents blood draining out of the brain tissues. [CDATA[> WebFactor V Leiden (FVL) is a change in your genes that affects one of the clotting factors in your blood and keeps your body's blood -clotting process from working right. I just read the post on the two individuals that developed blood clots after the Pfizer vaccine. This pointed the investigators to activity of factor V as well as factor VIII and factor X, two other major blood clotting protein factors. The waveform can actually be a useful tool to help assess patients as to whether their clinical course is declining toward DIC or not, Van Cott said. Copyright 2007-2023. There are many reports of small blood clots in multiple organs in COVID-19 patients causing organ damage, failure and death. However, there is no a priori reason to believe that replication-deficient vaccines should be unsafe in this setting. 3. This is a Moderna or Pfizer-BioNTech UPDATED BOOSTER This article is part of Harvard Medical Schoolscontinuing coverageof medicine, biomedical research, medical education and policy related to the SARS-CoV-2 pandemic and the disease COVID-19. The Johnson & Johnson COVID-19 vaccine was linked to an increased frequency of blood clotting, so I would not recommend that vaccine. There are a lot of things that still need to be explored. Before receiving a COVID-19 vaccine, you may be asked questions about your history of bleeding and your bleeding disorder. [CDATA[// >

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